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The circadian gene Dec2 promotes pancreatic cancer progression and dormancy through immune evasion
The body’s daily rhythm gene Dec2 may help pancreatic cancer grow and hide from the immune system
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Abstract
Deletion of the circadian rhythm gene Dec2 from tumor cells significantly increased mouse survival after pancreatic ductal adenocarcinoma resection.
- Increased survival was linked to an immune-mediated mechanism, as benefits were lost in immunodeficient mice.
- Dec2 is associated with promoting immune evasion by suppressing antigen presentation related to major histocompatibility complex class I (MHC-I).
- The presence of Dec2 also alters the tumor microenvironment from low to high T cell infiltration, indicating a shift from immune cold to hot.
- In vitro studies show that genes related to MHC-I antigen presentation exhibit circadian oscillation, a pattern disrupted by the deletion of Dec2.
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