Clinical cancer research : an official journal of the American Association for Cancer Research

Genetic differences in body clock genes and timing of prostate cancer radiotherapy may influence risk of late side effects

Updated

Abstract

Breast cancer patients with specific circadian rhythm genotypes may experience higher incidences of toxicity from radiotherapy.

  • Certain genetic profiles related to circadian rhythms are linked to increased treatment side effects in breast cancer patients.
  • The study suggests that treatment timing may influence toxicity levels in patients undergoing radiotherapy.
  • Similar effects are being investigated in prostate cancer to determine if time-of-day influences treatment outcomes.
  • Genetically-guided chronomodulation could potentially reduce side effects while maintaining treatment effectiveness.

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Funding

Competing interests

A.J. Webb reports grants from the European Union Seventh Framework Programme during the conduct of the study, as well as grants from Horizon Europe - PRE-ACT Project outside the submitted work. T. Rattay reports grants from the National Institute of Health and Care Research outside the submitted work. D.K. De Ruysscher reports grants from AstraZeneca and Bristol Myers Squibb, other support from Pfizer, and nonfinancial support from Olink outside the submitted work. L. Veldeman reports grants from the European Commission Seventh Framework during the conduct of the study. C.J. Talbot reports grants from Horizon Europe during the conduct of the study. No disclosures were reported by the other authors.
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