Genetic differences in body clock genes and timing of prostate cancer radiotherapy may influence risk of late side effects

Breast cancer patients with specific circadian rhythm genotypes may experience higher incidences of toxicity from radiotherapy.

• Certain genetic profiles related to circadian rhythms are linked to increased treatment side effects in breast cancer patients.
• The study suggests that treatment timing may influence toxicity levels in patients undergoing radiotherapy.
• Similar effects are being investigated in prostate cancer to determine if time-of-day influences treatment outcomes.
• Genetically-guided chronomodulation could potentially reduce side effects while maintaining treatment effectiveness.

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