Daily Rhythm Controls in Heart Failure: How Different Cells Regulate Timing and Potential Time-Based Treatments

Circadian rhythms may significantly influence the pathophysiology of heart failure.

• The circadian clock system regulates heart functions through interactions among various cell types, including heart muscle cells and supporting cells.
• Circadian rhythms are associated with processes such as energy metabolism, tissue inflammation, and fibrosis in heart failure.
• Cell-specific circadian regulation suggests that different types of cells, like cardiomyocytes and vascular cells, play distinct roles in heart failure development.
• Synchronizing internal biological clocks with external time cues could help prevent heart failure or support rehabilitation efforts.
• Chronotherapeutic strategies focusing on biological timing may offer new approaches to managing heart failure.

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