Prevalence of Circadian Misalignment and Its Association With Depressive Symptoms in Delayed Sleep Phase Disorder

Apr 2, 2017Sleep

How Common Sleep Timing Misalignment Relates to Depression Symptoms in People with Delayed Sleep Phase Disorder

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Abstract

Fifty-seven percent of patients diagnosed with delayed sleep phase disorder (DSPD) were classified as having circadian DSPD, with dim light melatonin onset occurring 1.66 hours later than in non-circadian DSPD.

Circadian DSPD patients exhibited moderate to severe depressive symptoms at a rate of 14.0%, compared to 3.8% in non-circadian DSPD patients.
Circadian DSPD is associated with 4.31 times increased odds of experiencing at least mild depressive symptoms.
No significant differences were observed in daytime sleepiness or functioning between the two groups.
Clinicians rated DSPD symptoms as more severe in patients with circadian DSPD.

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STUDY OBJECTIVE: To examine the prevalence of circadian misalignment in clinically diagnosed delayed sleep phase disorder (DSPD) and to compare mood and daytime functioning in those with and without a circadian basis for the disorder.

METHODS: One hundred and eighty-two DSPD patients aged 16-64 years, engaged in regular employment or school, underwent sleep-wake monitoring in the home, followed by a sleep laboratory visit for assessment of salivary dim light melatonin onset (DLMO). Based on the DLMO assessments, patients were classified into two groups: circadian DSPD, defined as DLMO occurring at or after desired bedtime (DBT), or non-circadian DSPD, defined as DLMO occurring before DBT.

RESULTS: One hundred and three patients (57%) were classified as circadian DSPD and 79 (43%) as non-circadian DSPD. DLMO occurred 1.66 hours later in circadian DSPD compared to non-circadian DSPD (p < .001). Moderate-severe depressive symptoms (Beck Depression Inventory-II) were more prevalent in circadian DSPD (14.0%) than in non-circadian DSPD (3.8%; p < .05). Relative to non-circadian DSPD patients, circadian DSPD patients had 4.31 times increased odds of at least mild depressive symptoms (95% CI 1.75 to 10.64; p < .01). No group differences were found for daytime sleepiness or function, but DSPD symptoms were rated by clinicians to be more severe in those with circadian DSPD.

CONCLUSIONS: Almost half of patients clinically diagnosed with DSPD did not show misalignment between the circadian pacemaker and the DBT, suggesting that the reported difficulties initiating sleep at the DBT are unlikely to be explained by the (mis)timing of the circadian rhythm of sleep propensity. Circadian misalignment in DSPD is associated with increased depressive symptoms and DSPD symptom severity.

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Prevalence of Circadian Misalignment and Its Association With Depressive Symptoms in Delayed Sleep Phase Disorder

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