Normal body clock timing requires REV-ERB proteins to suppress Npas2

Loss of REV-ERB nuclear receptors in the suprachiasmatic nucleus leads to a marked shortening of the circadian period.

• The shortening of the circadian period due to REV-ERB loss is tissue autonomous.
• This effect is consistent in both brain and liver tissues.
• Period shortening occurs through the derepression of clock transcription factors NPAS2 and CLOCK.
• REV-ERB loss alters core circadian properties and has tissue-specific consequences.

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