We can’t show the full text here under this license. Use the link below to read it at the source.
Normal circadian period length requires repression of Npas2 by REV-ERB nuclear receptors
Normal body clock timing requires REV-ERB proteins to suppress Npas2
AI simplified
Abstract
Loss of REV-ERB nuclear receptors in the suprachiasmatic nucleus leads to a marked shortening of the circadian period.
- The shortening of the circadian period due to REV-ERB loss is tissue autonomous.
- This effect is consistent in both brain and liver tissues.
- Period shortening occurs through the derepression of clock transcription factors NPAS2 and CLOCK.
- REV-ERB loss alters core circadian properties and has tissue-specific consequences.
AI simplified