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In vitro regulation of circadian phosphorylation rhythm of cyanobacterial clock protein KaiC by KaiA and KaiB
How KaiA and KaiB proteins control daily phosphorylation cycles of the cyanobacterial clock protein KaiC in the lab
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Abstract
The biochemical oscillation of KaiC phosphorylation is central to the cyanobacterial circadian clock.
- KaiC and KaiB levels inside cells fluctuate in a circadian manner.
- Different concentrations of Kai proteins influence the rhythm of KaiC phosphorylation.
- KaiA may adjust the parameters of the phosphorylation rhythm, while KaiB could switch the state of this rhythm.
- The variations in intracellular Kai protein levels may help synchronize the cellular circadian clock.
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