FEBS letters

How KaiA and KaiB proteins control daily phosphorylation cycles of the cyanobacterial clock protein KaiC in the lab

Circadian Biology Weekly Brief ↗PubMed ↗DOI ↗

Updated

Abstract

The biochemical oscillation of KaiC phosphorylation is central to the cyanobacterial circadian clock.

  • KaiC and KaiB levels inside cells fluctuate in a circadian manner.
  • Different concentrations of Kai proteins influence the rhythm of KaiC phosphorylation.
  • KaiA may adjust the parameters of the phosphorylation rhythm, while KaiB could switch the state of this rhythm.
  • The variations in intracellular Kai protein levels may help synchronize the cellular circadian clock.

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