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Circadian regulation of hydroxyindole-O-methyltransferase mRNA in the chicken pineal gland in vivo and in vitro
Daily rhythm of an enzyme’s gene activity in the chicken’s pineal gland inside the body and in lab conditions
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Abstract
A day/night rhythm of hydroxyindole-O-methyltransferase (HIOMT) mRNA levels peaks at midlight phase.
- HIOMT mRNA levels show circadian variations, with high expression at night and a peak during the midlight phase.
- The observed rhythm of HIOMT mRNA persists in constant darkness, indicating an endogenous regulatory mechanism.
- Light exposure during the dark phase stimulates HIOMT mRNA levels in both in vivo and in vitro conditions.
- HIOMT mRNA stability remains unchanged under varying light or dark conditions, suggesting consistency in expression.
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