Molecular vision

Daily rhythms of a clock gene’s light signal in the mouse eye’s support layer

Circadian Biology Weekly Brief ↗PubMed ↗

Updated

Abstract

Per2 mRNA levels in the RPE-choroid show a clear circadian rhythm in vivo.

  • A circadian rhythm in bioluminescence was observed in cultured RPE-choroid explants from PER2::LUC knockin mice.
  • Light exposure during subjective night did not shift the phase of the circadian rhythm in bioluminescence.
  • Removal of the suprachiasmatic nuclei did not impact the circadian rhythm of bioluminescence in the RPE-choroid.
  • These findings suggest that the regulation of the circadian rhythm in the RPE-choroid is independent of traditional central circadian control.

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