Circadian rhythm of amyloid-β in the olfactory bulb and cerebellum of wild-type and APPxPS1 knock-in mice indicates a loss of rhythmicity in regions more vulnerable to amyloid pathology

N = 128 mice were used to investigate differences in amyloid-β (Aβ) accumulation between the olfactory bulbs and cerebellum.

• A robust circadian rhythm of Aβ was confirmed in the mouse brain.
• The olfactory bulbs exhibited more overall Aβ accumulation than the cerebellum.
• The circadian Aβ rhythm was absent in the olfactory bulbs of the knock-in mice compared to wild type mice.
• No differences in the Aβ rhythm were observed in the cerebellum between the two genotypes.
• The loss of Aβ rhythm in specific brain regions may be associated with the development of Alzheimer's Disease pathology.

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