The interplay between circadian rhythm components and apoptosis in health and disease

📖 Top 20% JournalJan 31, 2026Human cell

How body clock systems and cell death interact in health and disease

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Circadian Biology on OpenScience ↗PubMed ↗DOI ↗

Abstract

Circadian rhythm influences the expression of numerous protein-coding genes, which is central to maintaining health.

Circadian rhythms interact with various intracellular signaling pathways.
These interactions may govern different molecular mechanisms related to pathologies.
The relationship between circadian rhythms and apoptosis could be crucial for health and disease.
Alterations in apoptosis are observed during cancer progression and in autoimmune and neurodegenerative diseases.
Circadian components and apoptotic factors may interact bidirectionally, providing insights into disease development.

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In humans, circadian rhythm regulates the expression of numerous protein-coding genes across nearly all cell types, playing a central role in maintaining health. However, circadian rhythm components interact with a wide variety of intracellular signaling pathways. Through these interactions, the circadian system interfaces with various pathologies by governing different molecular mechanisms. Evidence suggests that the interaction between circadian rhythms and apoptosis plays a pivotal role in both health and disease, warranting careful investigation. Apoptosis, one of the main mechanisms of programmed cell death, is essential for establishing maintaining cellular homeostasis in the human body. Alterations in apoptotic activity occur during the progression of cancer, as well as in various autoimmune and neurodegenerative diseases. Conversely, bidirectional interactions between circadian components and apoptotic factors offer new insights into disease development. Therefore, this review highlights the links between circadian rhythms and apoptosis across health and disease states, aiming to identify potential therapeutic interventions based on this connection.

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