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Circadian rhythm-guided cellular therapy in hematologic malignancies: mechanisms, clinical evidence, and optimization strategies
Using the body's daily rhythms to improve cell therapy for blood cancers: how it works, clinical results, and ways to make it better
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Abstract
Circadian disruption is associated with the initiation and progression of hematologic malignancies.
- Circadian rhythms coordinate blood cell production and immune function via central and peripheral clocks.
- Hematologic malignancies may be influenced by circadian disruptions, affecting tumor development and treatment responses.
- Cellular therapies like hematopoietic stem cell transplantation (HSCT) and chimeric antigen receptor T-cell therapy (CAR-T) show significant clinical effectiveness.
- Circadian regulation plays a critical role in the outcomes and toxicities of HSCT and CAR-T therapies.
- Opportunities for chronotherapy include optimizing the timing of cell collection, manufacturing, infusion, and post-treatment care.
- Individualized circadian phase assessment could help personalize treatment scheduling for improved patient outcomes.
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