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Timing Matters: Circadian Rhythm Disruption in Alcohol-Associated Peripheral Organ Pathophysiology
Disrupting the Body’s Daily Clock in Alcohol-Related Damage to Organs
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Abstract
Circadian disruption may increase alcohol-induced gut permeability, systemic inflammation, and liver disease.
- Alcohol disrupts circadian regulation in various organs, including the liver and intestine.
- Circadian disruption is associated with increased metabolic dysfunction and organ injury.
- Both genetic and environmental factors contribute to circadian disruption and its effects on alcohol toxicity.
- Other lifestyle factors, such as diet and smoking, may worsen circadian disruption and alcohol-related harm.
- Emerging therapeutic strategies based on circadian biology could improve treatment for alcohol-associated diseases.
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