Timing Matters: Circadian Rhythm Disruption in Alcohol-Associated Peripheral Organ Pathophysiology

Circadian disruption may increase alcohol-induced gut permeability, systemic inflammation, and liver disease.

• Alcohol disrupts circadian regulation in various organs, including the liver and intestine.
• Circadian disruption is associated with increased metabolic dysfunction and organ injury.
• Both genetic and environmental factors contribute to circadian disruption and its effects on alcohol toxicity.
• Other lifestyle factors, such as diet and smoking, may worsen circadian disruption and alcohol-related harm.
• Emerging therapeutic strategies based on circadian biology could improve treatment for alcohol-associated diseases.

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