Circadian rhythm disruption and endocrine-related tumors

No SJR dataJul 29, 2024World journal of clinical oncology

Disrupted Body Clocks and Hormone-Related Tumors

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Abstract

Circadian disruption is associated with increased risks of adverse health outcomes, including metabolic syndrome and various cancers.

Circadian clocks regulate essential processes such as the sleep-wake cycle, energy metabolism, immune function, and cell proliferation.
The central oscillator in the hypothalamic suprachiasmatic nucleus synchronizes with light-dark cycles, while peripheral clocks respond to feeding times.
Specific links exist between circadian disruption and endocrine tumors, including breast, ovarian, and prostate cancers.
Shift work is associated with a higher risk of breast cancer, with gene expression influencing tumor progression and drug resistance.
Factors such as aging and intermittent fasting may impact prostate cancer outcomes in relation to circadian rhythms.
Integrating biological timing into clinical practices may enhance personalized healthcare and lead to novel therapeutic approaches.

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This review delved into the intricate relationship between circadian clocks and physiological processes, emphasizing their critical role in maintaining homeostasis. Orchestrated by interlocked clock genes, the circadian timekeeping system regulates fundamental processes like the sleep-wake cycle, energy metabolism, immune function, and cell proliferation. The central oscillator in the hypothalamic suprachiasmatic nucleus synchronizes with light-dark cycles, while peripheral tissue clocks are influenced by cues such as feeding times. Circadian disruption, linked to modern lifestyle factors like night shift work, correlates with adverse health outcomes, including metabolic syndrome, cardiovascular diseases, infections, and cancer. We explored the molecular mechanisms of circadian clock genes and their impact on metabolic disorders and cancer pathogenesis. Specific associations between circadian disruption and endocrine tumors, spanning breast, ovarian, testicular, prostate, thyroid, pituitary, and adrenal gland cancers, are highlighted. Shift work is associated with increased breast cancer risk, withgenes influencing tumor progression and drug resistance.gene expression correlates with cisplatin resistance in ovarian cancer, while factors like aging and intermittent fasting affect prostate cancer. Our review underscored the intricate interplay between circadian rhythms and cancer, involving the regulation of the cell cycle, DNA repair, metabolism, immune function, and the tumor microenvironment. We advocated for integrating biological timing into clinical considerations for personalized healthcare, proposing that understanding these connections could lead to novel therapeutic approaches. Evidence supports circadian rhythm-focused therapies, particularly chronotherapy, for treating endocrine tumors. Our review called for further research to uncover detailed connections between circadian clocks and cancer, providing essential insights for targeted treatments. We emphasized the importance of public health interventions to mitigate lifestyle-related circadian disruptions and underscored the critical role of circadian rhythms in disease mechanisms and therapeutic interventions. PER CLOCK

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Abstract

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