Disrupted Body Clocks and Cell Damage in High Blood Pressure: Causes and Treatment Ideas

Circadian disruption may lower the threshold for ferroptosis in cardiovascular and renal tissues.

• Hypertension shows a significant circadian rhythm, with temporal imbalances potentially leading to vascular and renal injury.
• Circadian misalignment is associated with endothelial dysfunction, vascular remodeling, and renal injury.
• Oxidative stress dysregulation could drive ferroptosis, a form of cell death, in the context of hypertension.
• A mismatch between oxidative stress generation and antioxidant defense may amplify hemodynamic stress.
• Impairment of endothelial integrity and renal sodium handling is linked to the development and progression of hypertension.
• Current evidence suggests a mechanistic connection between circadian biology and structural organ damage, although direct causal evidence is limited.

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