Clinicopathological significance of circadian rhythm‐related gene expression levels in patients with epithelial ovarian cancer

In epithelial ovarian cancer, cry1 expression is significantly higher compared to normal ovaries among the clock genes studied.

• Expression levels of per1, per2, cry2, clock, and CKIepsilon were significantly lower in ovarian cancer tissues than in normal tissues.
• Cry1 expression was the highest among the examined clock genes and was much higher in ovarian cancer tissues compared to normal ovaries.
• Cry1 expression was significantly reduced in mucinous and grade 3 tumors, while Bmal1 expression was notably lower in mucinous adenocarcinomas compared to other histologies.
• The combination of low cry1 and low Bmal1 expression was identified as an independent prognostic factor alongside stage and histological subtype.
• Antiphase expression patterns of cry1 and Bmal1 may be preserved in ovarian cancers.

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