Circadian rhythm gene levels linked to disease features in ovarian cancer patients

In epithelial ovarian cancer, cry1 expression is significantly higher compared to normal ovaries among the clock genes studied.

• Expression levels of per1, per2, cry2, clock, and CKIepsilon were significantly lower in ovarian cancer tissues than in normal tissues.
• Cry1 expression was the highest among the examined clock genes and was much higher in ovarian cancer tissues compared to normal ovaries.
• Cry1 expression was significantly reduced in mucinous and grade 3 tumors, while Bmal1 expression was notably lower in mucinous adenocarcinomas compared to other histologies.
• The combination of low cry1 and low Bmal1 expression was identified as an independent prognostic factor alongside stage and histological subtype.
• Antiphase expression patterns of cry1 and Bmal1 may be preserved in ovarian cancers.

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