Loss of circadian rhythm of circulating insulin concentration induced by high-fat diet intake is associated with disrupted rhythmic expression of circadian clock genes in the liver

Mice fed a high-fat diet for 80 days showed continuously higher serum insulin concentrations during the day compared to control mice.

• Feeding on a high-fat diet disrupted the normal circadian rhythm of clock genes in the liver.
• Expression of genes related to fat production peaked at a specific time in control mice but was reduced in those on a high-fat diet.
• Transcription factors Bmal1 and Clock exhibited circadian variation in control mice, which was not observed in high-fat diet mice.
• The findings suggest a link between disrupted insulin secretion patterns and altered expression of metabolic and clock genes.

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