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Abstract
Simulations show that circadian fluctuations in ionic dynamics modify neuronal excitability and seizure onset.
- A circadian modulation was introduced into the Epileptor-2 model to study its effects on epileptic seizures.
- Daily fluctuations in neuronal excitability were modeled to understand their impact on seizure occurrence.
- Pharmacokinetics of antiepileptic drugs were adjusted according to circadian rhythms to evaluate their effectiveness.
- Optimizing the timing of drug doses to coincide with periods of highest seizure susceptibility may enhance treatment outcomes.
- Results indicate a mechanistic link between ionic dynamics and biological rhythms related to epilepsy.
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