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From Rhythm to Resilience: The Interplay of Circadian Rhythm, Melatonin, Lifestyle, Nutrition in Psychoneuroimmunology (PNI)
How daily body clocks, melatonin, lifestyle, and nutrition interact in mind-body immune health
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Abstract
Circadian disruptions and lifestyle imbalances may contribute to neuroinflammation, mood dysregulation, and cardiometabolic dysfunction.
- Circadian rhythm, melatonin signaling, nutrition, and inflammation are interconnected factors affecting mental and physical health.
- Conditions such as attention-deficit/hyperactivity disorder (ADHD), major depressive disorder (MDD), and metabolic syndrome are associated with these disruptions.
- Therapeutic potential has been highlighted for omega-3 polyunsaturated fatty acids (n-3 PUFAs) and the neuroprotective effects of paeoniflorin.
- Extracellular matrix gene variants may influence vulnerability to MDD.
- Lifestyle interventions, including Tai Chi, provide support for non-pharmacological approaches to enhance mental resilience.
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