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Circadian rhythm of melatonin release in pineal gland culture: arg-vasopressin inhibits melatonin release
Daily cycle of melatonin release in pineal gland cells: arginine vasopressin reduces melatonin production
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Abstract
AVP (1 microM) suppressed melatonin release from pineal gland explant cultures.
- Melatonin release is regulated by AVP, which is released from the suprachiasmatic nucleus.
- Noradrenaline, which normally stimulates melatonin release, has its effect reduced by AVP.
- Melatonin levels in the suprachiasmatic nucleus are higher during the dark period compared to the light period.
- This pattern of melatonin expression persists even under constant dim light conditions.
- The findings suggest a reciprocal regulatory relationship between melatonin and AVP in the SCN and pineal gland.
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