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Circadian rhythm, metabolic stress, and Alzheimer’s disease
Daily Body Clocks, Metabolic Stress, and Alzheimer's Disease
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Abstract
Metabolic stresses may exacerbate Alzheimer's disease through impaired glucose utilization and gut-brain axis dysfunction.
- Alzheimer's disease involves both genetic and acquired factors, including lifestyle changes and infections.
- Circadian rhythms regulate brain energy metabolism and influence gut microbiota composition.
- Gut-derived metabolites can affect the expression of genes related to circadian rhythms and neuroinflammation.
- Metabolic stresses contribute to systemic inflammation and gut dysbiosis, potentially worsening Alzheimer’s disease.
- Dietary patterns, such as time-restricted feeding, may support circadian rhythms and reduce neuroinflammation.
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