Daily patterns of Alzheimer’s-related molecules are disrupted in the brain fluid-producing tissue of female Alzheimer's mice

Aβ uptake displayed circadian rhythmicity.

• The choroid plexus is a key part of the blood-cerebrospinal fluid barrier and plays a role in the circadian clock system.
• Angiotensin-converting enzyme (Ace) and transthyretin (Ttr) showed significant rhythmic expression in specific groups of mice.
• Inadequate clearance of amyloid-β (Aβ) is linked to circadian dysfunctions in Alzheimer's disease patients.
• The circadian expression of Aβ scavengers may influence the rhythmicity of Aβ uptake.
• Results suggest that Alzheimer’s disease may disrupt the rhythmic expression of Aβ scavengers.

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