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Loss of circadian rhythmicity in bdnf knockout zebrafish larvae
Loss of daily activity cycles in zebrafish larvae lacking a key brain growth protein
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Abstract
In zebrafish with a Bdnf null mutant line, 66% of coding genes and 37% of microRNAs are differentially expressed compared to wild type siblings.
- No morphological defects were observed in the Bdnf null mutant zebrafish.
- Significant alterations in the rhythmic expression of clock and clock-controlled genes were confirmed.
- Behavioral tests indicated an absence of circadian activity rhythms in the larvae.
- Pharmacological treatment partially rescued the circadian behavior.
- This zebrafish model offers a stable platform for investigating BDNF-related neurodevelopmental diseases.
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