Body Clock Effects on Drug Response and Personalized Dosing

Circadian rhythms may influence drug efficacy and toxicity depending on the time of administration.

• Molecular clocks in the suprachiasmatic nucleus and peripheral oscillators regulate drug metabolism and response.
• Variability in drug action is associated with the timing of administration, impacting both pharmacokinetics and pharmacodynamics.
• Chronotherapeutic strategies are being explored for diseases such as cancer, cardiovascular disease, and bipolar disorder.
• Wearable technologies could facilitate time-resolved evaluations of drug responses.
• Challenges exist in translating circadian timing considerations into clinical practice and precision medicine.

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