Circadian Rhythms, Metabolic Disorders, and Cardiovascular Aging: Molecular Crosstalk and Clinical Translation
How Body Clocks, Metabolism Problems, and Heart Aging Are Linked at the Molecular Level and What This Means for Treatment
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Abstract
Disruptions in circadian rhythms are closely associated with metabolic dysfunction and accelerated cardiovascular aging.
- Age-related declines in circadian clock function may contribute to metabolic imbalances and cardiovascular decline.
- Inflammation, oxidative stress, and mitochondrial dysfunction are pathways involved in the effects of circadian dysregulation.
- Complex molecular networks have been identified that link circadian dysregulation to metabolic disorders and cardiovascular diseases.
- Potential therapeutic targets include sirtuin 1, peroxisome proliferator-activated receptor α, and reverse erythroblastosis virus α.
- Interventions based on circadian principles, such as time-restricted eating and chronotherapy, show promise in mitigating cardiovascular aging.
- Challenges remain for clinical implementation due to a lack of large-scale trials and real-world barriers.
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