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The role of circadian rhythms and sleep in the aetiology of autism spectrum disorder and attention-deficit/hyperactivity disorder: New evidence from bidirectional two-sample Mendelian randomization analysis
How body clock and sleep may be linked to autism and ADHD: new genetic evidence
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Abstract
Changes in are linked to autism spectrum disorder and attention-deficit/hyperactivity disorder.
- People with autism spectrum disorder and attention-deficit/hyperactivity disorder often experience sleep issues and disrupted circadian rhythms.
- The timing of peak activity hours may increase the likelihood of having both autism spectrum disorder and attention-deficit/hyperactivity disorder.
- Good sleep quality could protect against autism spectrum disorder.
- Disturbed sleep in individuals with attention-deficit/hyperactivity disorder may result from the condition rather than cause it.
- The findings suggest that sleep and body rhythms play a role in the management of these disorders.
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Key numbers
29.640
Increase in ASD risk
Odds ratio for genetically predicted linked to ASD
7.703
Increase in ADHD risk
Odds ratio for genetically predicted linked to ADHD
0.155
Protective effect on ASD
Odds ratio for sleep efficiency's effect on ASD