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Circadian therapy interventions for glymphatic dysfunction in concussions injuries: A narrative review
Using Daily Rhythm Treatments to Improve Waste Clearance Problems After Concussions
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Abstract
Buildup of neurotoxic proteins in the brain after concussion poses significant threats.
- A sustained neuroinflammatory response may result from the accumulation of neurotoxic proteins.
- This neuroinflammation is linked to central sensitization and persistent post-concussive symptoms.
- The brain's is essential for clearing neurotoxic waste and is affected by sleep cycles.
- Glymphatic dysfunction and sleep disturbances are common in the acute phase following a concussion.
- Optimizing sleep through may be crucial for effective management of acute concussion.
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Key numbers
70%
Sleep Disturbance Prevalence
Percentage of concussion cases affected by sleep disturbances.
up to 60%
Glymphatic Dysfunction Impairment
Percentage of glymphatic function impairment observed in animal models post-TBI.
3.5 vs. 8 days
Recovery Time Comparison
Recovery time in days for screen time-restricted vs. unrestricted groups.