Science progress

Using Daily Rhythm Treatments to Improve Waste Clearance Problems After Concussions

Updated

Abstract

Buildup of neurotoxic proteins in the brain after concussion poses significant threats.

  • A sustained neuroinflammatory response may result from the accumulation of neurotoxic proteins.
  • This neuroinflammation is linked to central sensitization and persistent post-concussive symptoms.
  • The brain's is essential for clearing neurotoxic waste and is affected by sleep cycles.
  • Glymphatic dysfunction and sleep disturbances are common in the acute phase following a concussion.
  • Optimizing sleep through may be crucial for effective management of acute concussion.

Simplified

Key numbers

70%
Sleep Disturbance Prevalence
Percentage of concussion cases affected by sleep disturbances.
up to 60%
Glymphatic Dysfunction Impairment
Percentage of glymphatic function impairment observed in animal models post-TBI.
3.5 vs. 8 days
Recovery Time Comparison
Recovery time in days for screen time-restricted vs. unrestricted groups.

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Funding

Competing interests

The author(s) declared the following potential conflicts of interest with respect to the research, authorship, and/or publication of this article: All authors of this manuscript are affiliated with TBI Virtual, a for-profit telemedicine clinic whose primary focus is the treatment of concussion injuries. This manuscript reflects the treatment philosophy and practices of TBI Virtual and as such, represents for-profit services offered by the clinic.
PubMed

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