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Circadian timing and entrainment properties of the SCN pacemaker in the PS19 mouse model of tau pathology
Daily rhythm and adjustment of the brain's internal clock in a mouse model of tau-related brain disease
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Abstract
Accumulation of phosphorylated tau was observed in the suprachiasmatic nucleus of PS19 mice as early as 2 months of age.
- Tau pathology was identified in both major neuronal subpopulations of the suprachiasmatic nucleus: VIPergic and AVPergic neurons.
- Monitoring of daily locomotor activity from 3 to 11 months showed no significant differences in activity profiles between PS19 and wild-type mice.
- Rates of re-entrainment to changes in the light/dark cycle were largely unaffected in PS19 mice compared to age-matched wild-type mice.
- Profiling of circadian gene expression in tau fibril-seeded suprachiasmatic nucleus explants revealed no differences in network-level oscillator properties.
- Findings suggest that tau pathology in the suprachiasmatic nucleus may not cause major disruptions in core circadian timing mechanisms.
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