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Circadian variations of plasma TSH in patients with severe hypothyroidism
Daily changes in blood thyroid-stimulating hormone levels in people with severe underactive thyroid
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Abstract
A statistically significant circadian rhythm in TSH was detected with the acrophase at 23:30.
- Serum TSH levels were lower during the day and higher at night in patients with severe hypothyroidism.
- No significant diurnal variation was found for serum T3 levels.
- The TSH pattern in these patients was similar to that seen in normal and mildly hypothyroid individuals.
- The circadian rhythm of TSH appears to be retained despite severe hypothyroidism.
- Thyroid function abnormalities do not affect the regulation of TSH periodicity.
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