circHERC1 as a molecule that activates telomerase

CircHERC1 expression declines with age, which is associated with reduced telomerase activity.

• CircHERC1 regulates the transcription of telomerase reverse transcriptase (TERT) by binding to its promoter.
• The recruitment of RNA polymerase II and c-Fos is facilitated by circHERC1, activating TERT expression.
• Restoring circHERC1 expression enhances telomerase activity and promotes telomere elongation.
• CircHERC1 delivery through viral vectors or extracellular vesicles effectively restores telomerase activity and preserves telomere integrity.
• This intervention may improve cognitive function, physical performance, and reduce inflammation.

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