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Abstract
Circular RNAs (circRNAs) may offer a stable platform for therapeutic and vaccine development.
- circRNAs have a covalently closed-loop structure that provides stability and resistance to degradation.
- They can initiate translation independently of the cap structure, which may enhance their therapeutic applications.
- circRNAs could address limitations of traditional linear RNA molecules, such as short half-life and instability.
- These RNA-based vaccines may elicit strong immune responses by encoding specific antigens.
- circRNAs are involved in gene regulation through mechanisms like acting as microRNA sponges.
- They may also have potential as diagnostic biomarkers in various diseases.
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