Circular RNA vaccine with combined B6 and M1 proteins triggers strong immunity against monkeypox virus

The bivalent circular RNA vaccine provides complete protection to immunized mice against a lethal virus challenge.

• The vaccine encodes a chimeric immunogen that combines two key MPXV antigens.
• It preserves the structure of major neutralizing sites from both antigens.
• The vaccine induces strong neutralizing antibodies against both MPXV and VACV.
• It also stimulates specific T cell responses related to the antigens.
• Findings suggest potential for developing advanced circRNA vaccines targeting MPXV and similar viruses.

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