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Circulating cell type senescence signatures track distinct dimensions of health status and trajectories in human longitudinal cohorts
Signs of cell aging in the blood reflect different aspects of health and changes over time in people
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Abstract
Pooled senescence proteins outperform non-senescence proteins in predicting clinical parameters such as age and hypertension.
- Circulating senescence signatures are linked to age-related traits and diseases.
- Senescence signatures from 14 human cell types were analyzed for clinical relevance in two longitudinal studies with 2,272 participants combined.
- Cell type senescence signatures often correlate strongly with their respective health domains.
- The immune cell senescence signature is associated with higher mortality and future disease onset.
- Circulating biomarkers of senescence may provide a more detailed assessment of health status.
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