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Circulating senescence-associated secretory phenotype factors across the stages of type 1 diabetes in a cross-sectional cohort
Levels of aging-related inflammatory factors in the blood during different stages of type 1 diabetes
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Abstract
Higher concentrations of specific islet-associated factors were observed in recent onset Type 1 diabetes (T1D) donors compared to controls.
- Seven human islet-secreted SASP factors were measured in pediatric and young adult plasma samples.
- SASP factor concentrations were elevated in stages 1, 2, and 3 of recent onset T1D compared to autoantibody-negative controls.
- The levels of SASP factors effectively distinguished between stages 2 and 3 of T1D progression.
- No correlation was found between SASP factor levels and beta cell dysfunction, autoantibody titre, or donor age.
- Analysis of plasma and pancreas samples from independent donors indicated a relationship between senescent beta cells and circulating SASP markers.
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Key numbers
4 of 7
Increase in Factors
factors were higher in stages 2 and 3 donors compared to controls.
0.96
for
Receiver Operating Characteristic (ROC) analysis for stage 3 identification.