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Levels of aging-related inflammatory factors in the blood during different stages of type 1 diabetes
Updated
Abstract
Essence
Circulating islet-associated factors may mark senescent beta-cell burden during type 1 diabetes progression.
Evidence
A blinded cross-sectional TrialNet plasma study of pediatric and young adult donors measured seven SASP factors in controls, single-autoantibody-positive donors, and clinical T1D stages, with n=20 per group and independent matched plasma-pancreas support.
Caveat
The cohort was small and cross-sectional, and SASP concentrations did not associate with beta-cell dysfunction, autoantibody titre, or donor age.
Simplified
Key numbers
4 of 7
Increase in Factors
factors were higher in stages 2 and 3 donors compared to controls.
0.96
for
Receiver Operating Characteristic (ROC) analysis for stage 3 identification.