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Abstract
Aging involves a complex network of blood-borne signals that connect various biological processes.
- Aging is characterized by systemic communication rather than isolated organ decline.
- The concept of the circulating senosome encompasses various age-related blood components.
- Circulating mediators linked to aging include proteins, vesicles, cytokines, lipids, and microbiome products.
- Blood serves as both a marker and a potential target for therapeutic interventions in aging.
- This framework highlights interactions among multiple established hallmarks of aging.
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