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Cistanche deserticola polysaccharides alleviate cognitive decline in aging model mice by restoring the gut microbiota-brain axis
Cistanche deserticola polysaccharides may reduce memory loss in aging mice by improving gut bacteria and brain communication
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Abstract
Prolonged administration of D-galactose to mice induced cognitive decline and gut microbial dysbiosis.
- Cognitive impairment in aging may be linked to changes in the gut microbiota-brain axis.
- D-galactose treatment led to cognitive decline, increased inflammation, and oxidative stress in mice.
- Polysaccharides (CDPS) improved cognitive function by restoring balance in gut microbes and reducing inflammation.
- The positive effects of CDPS were negated when gut microbiota were disrupted by antibiotics or immunosuppressive treatment.
- Serum metabolomic profiling revealed altered levels of several metabolites in aging model mice, which were normalized by CDPS.
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