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Abstract
Histone deacetylase (HDAC) enzymes play a crucial role in modifying specific proteins in the body.
- HDACs remove acyl-based modifications from lysine residues, influencing protein function.
- Different HDAC isozymes target distinct proteins and have varying cellular locations.
- Peptide-based tools have been developed to reveal the activities and substrate preferences of HDACs.
- HDACs are significant drug targets, with several approved treatments such as romidepsin.
- The future of HDAC research may involve high-throughput peptide technologies for better profiling and inhibitor discovery.
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