Temporal Gradient in the Clock Gene and Cell-Cycle Checkpoint KinaseWee1Expression along the Gut

The study found that the upper part of the rat gut exhibits a phase-advanced circadian clock compared to the distal colon.

• Circadian clocks were identified in the rat colon, stomach, and jejunum.
• Different parts of the gut show rhythmic profiles in clock gene expression with specific phasing differences.
• The upper gut, represented by the duodenum, was found to be synchronized but phase-advanced relative to the lower gut, represented by the colon.
• The expression of core clock genes and the cell-cycle regulator Wee1 varied between the upper and lower parts of the gut.
• These findings suggest that individual circadian clocks may regulate cell cycle timing in different gut regions.

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