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Clock Modulation by Naringenin Suppresses Lipogenesis and Promotes Adipose Tissue Browning
Naringenin Influences Body Clock to Reduce Fat Creation and Increase Fat Burning in Fat Tissue
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Abstract
Naringenin administration in vivo reduced fat mass and body weight while enhancing insulin signaling.
- Naringenin may suppress lipid storage in fat cells and promote the conversion of white fat to brown fat.
- The compound activates a specific protein (RORα) that influences the body's internal clock and enhances the expression of clock-related genes.
- This clock modulation by naringenin appears to inhibit fat production in mature fat cells.
- Effects of naringenin on fat production were lost in fat cells lacking RORα, indicating dependence on this protein.
- In addition to reducing fat, naringenin treatment lowered levels of glucose and free fatty acids in the blood.
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Key numbers
significantly reduced
Body Weight Reduction
Naringenin treatment for 7 days in mice
10 µM
Lipid Accumulation Suppression
Naringenin concentration that significantly reduced lipid storage in mature adipocytes
60%–70%
RORα Dependency
Abalation efficiency of RORα in adipocyte-specific knockout mice