CellsOct 16, 2026

The role of daily rhythm disruption in Alzheimer's disease and its link to a type of cell damage called ferroptosis

Circadian Biology Weekly Brief ↗PubMed ↗DOI ↗OA ↗

Updated Oct 17, 2026

Abstract

Alzheimer's disease is linked to sleep disturbances and circadian dysfunction, which may precede clinical symptoms.

Sleep disruption and circadian dysfunction are frequently observed in Alzheimer's disease and may be connected to amyloid-β pathology.
Circadian regulation may influence several cellular processes related to Alzheimer's pathogenesis, including autophagy and ferroptosis.
Clockophagy, a selective autophagic process, is suggested as a potential link between circadian regulation and cellular stress responses.
Current evidence connects sleep disruption, circadian dysfunction, lipid peroxidation, and susceptibility to ferroptosis in Alzheimer's disease.
Further studies are needed to assess whether targeting clockophagy could impact neurodegenerative processes associated with Alzheimer's disease.

Simplified

Alzheimer's disease (AD) is frequently associated with sleep disturbances and circadian dysfunction, which may precede or accompany clinical manifestations and have been associated with amyloid-β (Aβ) pathology, tau abnormalities, oxidative stress, lipid peroxidation, and neuronal vulnerability. Increasing evidence suggests that circadian regulation intersects with multiple cellular processes implicated in AD pathogenesis, including autophagy and ferroptosis. Among these mechanisms, clockophagy, an SQSTM1/p62-mediated selective autophagic process involved in BMAL1 degradation, has recently emerged as a potential molecular link between circadian regulation and cellular stress responses. In this review, we summarize current evidence connecting sleep disruption, circadian dysfunction, lipid peroxidation, and ferroptotic susceptibility in AD, while highlighting the current limitations of mechanistic evidence. We further discuss the molecular basis of clockophagy and its potential relationship with BMAL1 regulation, oxidative lipid damage, and ferroptosis. Collectively, clockophagy is currently viewed as an emerging hypothesis that may contribute to AD-related pathological processes. Finally, we discuss potential therapeutic implications, including approaches targeting sleep and circadian organization, BMAL1-associated regulatory pathways, and lipid oxidative stress. Further studies are required to determine whether modulation of clockophagy can influence AD-related neurodegenerative processes.

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The role of daily rhythm disruption in Alzheimer's disease and its link to a type of cell damage called ferroptosis

Abstract

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