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Clocks out of sync: Increased epigenetic aging variability in multiple sclerosis
Greater differences in biological aging signs in multiple sclerosis
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Abstract
Epigenetic age acceleration (EAA) shows 1.5 times greater variability in individuals with multiple sclerosis compared to healthy controls.
- The standard deviation for PhenoAge in the secondary progressive MS group was 12.7.
- A significant difference in variance was confirmed between relapsing remitting MS, secondary progressive MS, and healthy controls, with a p-value of 0.017.
- The findings indicate that individuals with multiple sclerosis may experience greater variability in biological age markers.
- Future studies on epigenetic aging in multiple sclerosis may require larger sample sizes to address this heterogeneity.
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