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Abstract
Irisin, a circulating myokine, may enhance cognitive function and neuroprotection.
- Irisin is derived from the FNDC5 protein and is secreted by skeletal muscle during exercise.
- It is associated with the 'Browning' of white adipose tissue, which regulates energy metabolism.
- Irisin can cross the blood-brain barrier and may increase levels of brain-derived neurotrophic factor (BDNF) in the hippocampus.
- Higher BDNF expression is linked to improved learning and memory.
- Irisin has demonstrated neuroprotective effects in various disease models.
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