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Abstract
Age-related neurodegenerative diseases and age-related hearing loss are increasingly prevalent globally.
- Immune cells may link age-related neurodegenerative diseases and hearing loss through chronic inflammation and maladaptive repair mechanisms.
- Resident macrophages and infiltrating immune cells in the cochlea may disrupt synaptic integrity and promote hair cell and neuronal loss in response to injury and aging.
- Microglia in the central nervous system could exhibit exaggerated inflammatory responses and impaired clearance of debris due to age and disease-associated priming.
- Cochlear macrophages and CNS microglia may share transcriptional programs and signaling pathways, influencing their roles in repair and regeneration.
- Modulating immune cell activity could promote pro-regenerative phenotypes that aid in tissue recovery rather than injury.
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