Coffee Consumption and Invasive Breast Cancer Incidence among Postmenopausal Women in the Cancer Prevention Study-II Nutrition Cohort

Aug 21, 2020Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology

Coffee Drinking and Risk of Invasive Breast Cancer in Postmenopausal Women

AI simplified

Longevity & Aging on OpenScience ↗PubMed ↗DOI ↗

Abstract

Among 57,075 postmenopausal women, coffee consumption was not associated with invasive breast cancer risk.

Total, caffeinated, and decaffeinated coffee intake showed hazard ratios of 0.99, 0.96, and 1.06, respectively, when comparing higher consumption to lower consumption.
No significant link was found between coffee consumption and the risk of hormone receptor-positive or hormone receptor-negative breast tumors.
The study examined coffee consumption patterns in relation to breast cancer incidence over a follow-up period until June 2015.

AI simplified

BACKGROUND: There is limited evidence of a potential inverse association between coffee, particularly caffeinated coffee, consumption and postmenopausal breast cancer risk, and few studies have examined this association by tumor hormone receptor status. To provide further evidence, we examined total, caffeinated, and decaffeinated coffee consumption in relation to postmenopausal invasive breast cancer incidence overall, and by tumor estrogen receptor (ER) and/or progesterone receptor (PR) subtype.

METHODS: Among 57,075 postmenopausal women in the Cancer Prevention Study-II Nutrition Cohort who were cancer free and reported coffee intake in 1999, we identified 2,980 women diagnosed with invasive breast cancer during follow-up through June 2015. Multivariable-adjusted Cox proportional hazards regression was used to compute hazard ratios (HR) and 95% confidence intervals (CI).

RESULTS: Neither total, caffeinated, nor decaffeinated coffee consumption was associated with invasive breast cancer risk; HRs (95% CIs) comparing consumption of ≥2 cups per day with <1 cup per month were 0.99 (0.89-1.11), 0.96 (0.87-1.06), and 1.06 (0.95-1.19), respectively. Similarly, coffee consumption was not associated with risk of hormone receptor-positive (ERor PR) or hormone receptor-negative (ERand PR) breast tumors. + + --

CONCLUSIONS: These findings do not support an association between coffee consumption and invasive breast cancer risk among postmenopausal women.

IMPACT: This large prospective study contributes to the limited evidence on coffee consumption and breast cancer risk, finding no association overall or by tumor receptor subtype.

Full Text

Full text is available at the source.

View full text (PDF) ↗View full text ↗

Coffee Consumption and Invasive Breast Cancer Incidence among Postmenopausal Women in the Cancer Prevention Study-II Nutrition Cohort

Abstract

Full Text

You found one interesting study. We’ll send the next 7.

what lands in your inbox each week:

Recent issues from the longevity & aging brief

Abstract

Full Text

Related papers

You found one interesting study. We’ll send the next 7.

what lands in your inbox each week:

Recent issues from the longevity & aging brief