Mental and personal effects of small psilocybin doses in two long-term placebo-controlled studies

Microdosing psilocybin truffles did not significantly improve cognitive or emotional functioning compared to placebo.

• Neither behavioral nor subjective measures showed significant differences when comparing microdosing to placebo.
• Some initial effects in social cognition and mood were noted, but these were not significant after adjustments.
• Participants generally reported positive experiences, although negative bodily feelings were more common in the microdosing group.
• Participants remained unaware of whether they received microdosing or placebo during the trials.
• Further studies may investigate how individual differences affect responses to microdosing.

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