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Associations of combined phenotypic ageing and genetic risk with incidence of chronic respiratory diseases in the UK Biobank: a prospective cohort study
How physical aging signs and genetic risk together relate to new cases of chronic lung diseases
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Abstract
is associated with a 52% increased risk of idiopathic pulmonary fibrosis per 5-year increase.
- PhenoAgeAccel shows significant associations with increased risk of chronic respiratory diseases, including idiopathic pulmonary fibrosis, COPD, and asthma.
- Each 5-year increase in PhenoAgeAccel correlates with a hazard ratio of 1.52 for idiopathic pulmonary fibrosis, 1.54 for COPD, and 1.18 for asthma.
- Participants with high genetic risk and accelerated biological age exhibited the highest risk of developing IPF, COPD, and asthma.
- Mediation analysis suggests that PhenoAgeAccel may mediate 10-20% of the relationship between smoking and chronic respiratory diseases.
- Approximately 10% of the association between exposure to fine particulate matter and chronic respiratory disorders could also be mediated by PhenoAgeAccel.
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Key numbers
1.52
Increased Risk of IPF
Hazard ratio per 5-year increase in
5.24
Highest Risk for IPF with Genetic Risk
Hazard ratio for high genetic risk participants with high
20.1%
Mediation Proportion by
Mediation proportion for the association between smoking and IPF