Gene activity differences show unique anti-aging roles and teamwork among three probiotics in a worm model

Three probiotic strains significantly enhanced anti-aging biomarkers in Caenorhabditis elegans.

• Multi-strain probiotic combinations may be more effective than single strains in promoting healthy aging.
• The selected strains co-regulated evolutionarily conserved Wnt signaling pathways with distinct effects on metabolism and immune function.
• Lactiplantibacillus plantarum Q7 is associated with modulation of lipid metabolism and activation of longevity pathways.
• Bifidobacterium animalis subsp. lactis F1-7 may stimulate immune defense and protein stability regulation.
• Lacticaseibacillus paracasei J5 predominantly influences methionine metabolism and detoxification processes.
• The combination of these probiotics could expand the anti-aging regulatory network in C. elegans.

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