Compliance with a Healthful Plant-Based Diet Is Associated with Kidney Function in Patients with Autosomal Dominant Polycystic Kidney Disease

Aug 29, 2024Nutrients

Following a Healthy Plant-Based Diet Linked to Kidney Function in Patients with Inherited Kidney Disease

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Abstract

Among 106 ADPKD patients, 37 (34.91%) had advanced chronic kidney disease.

Patients with advanced chronic kidney disease had lower overall and healthful plant-based diet scores compared to those with early chronic kidney disease.
Higher unhealthful plant-based diet scores were found in patients with advanced chronic kidney disease.
A negative correlation exists between the healthful plant-based diet score and both the neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio.
Greater adherence to a healthful plant-based diet is inversely associated with advanced chronic kidney disease, with an odds ratio of 0.117.
Conversely, a higher unhealthful plant-based diet score is positively associated with advanced chronic kidney disease, with an odds ratio of 8.450.

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Autosomal dominant polycystic kidney disease (ADPKD) is a genetic kidney disorder with multiple cyst formation that progresses to chronic kidney disease (CKD) and end-stage kidney disease. Plant-based diets have attracted considerable attention because they may prevent CKD development. This study investigated whether adherence to a plant-based diet is associated with kidney function in patients with ADPKD. The overall plant-based diet index (PDI), healthful PDI (hPDI), and unhealthful PDI (uPDI) were calculated using dietary intake data. Among 106 ADPKD patients, 37 (34.91%) were classified as having advanced CKD (eGFR < 60 mL/min/1.73 m). The overall PDI and hPDI were lower, but the uPDI was higher in patients with advanced CKD than in those with early CKD. The hPDI was negatively correlated with the neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio. Moreover, the hPDI was inversely associated with advanced CKD [odds ratio (OR): 0.117 (95% confidence interval (CI): 0.039-0.351),< 0.001], and the uPDI was positively associated with advanced CKD [OR: 8.450 (95% CI: 2.810-25.409),< 0.001]. The findings of the current study demonstrate that greater adherence to a healthful plant-based diet is associated with improved kidney function in ADPKD patients. 2p p

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Compliance with a Healthful Plant-Based Diet Is Associated with Kidney Function in Patients with Autosomal Dominant Polycystic Kidney Disease

Abstract

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