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Abstract
Aging is associated with the accumulation of senescent cells and chronic inflammation driven by the senescence-associated secretory phenotype.
- The complement system is now recognized as an important network within cells, referred to as the complosome.
- Intracellular C3 and C5 engage in interactions with key cellular pathways that influence aging processes.
- IntC3 is linked to multiple aging-related issues such as cellular senescence, mitochondrial dysfunction, and genomic instability.
- Dysregulation of intC3 has organ-specific effects in aging across the brain, liver, eye, kidney, vasculature, lung, and immune system.
- Potential therapeutic strategies include complement inhibitors, senolytics, and advanced delivery methods, although gaps remain in the tools needed for targeted interventions.
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