Copper levels linked to ketamine's ability to reduce loss of pleasure in hard-to-treat depression

Ketamine may exhibit a fast antidepressant action in patients with treatment-resistant depression (TRD).

• Abnormal copper levels might be associated with symptoms of depression.
• There is a potential link between blood copper levels and psychometric measures in patients with TRD.
• Anhedonia, a significant symptom in depression, is assessed using the Snaith-Hamilton Pleasure Scale (SHAPS).
• The study focuses on patients with major depressive disorder (MDD) and bipolar disorder (BP).

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