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Abstract
Copper selectively preserved survival in Saccharomyces cerevisiae under nutrient-limited conditions.
- Copper and iron are linked micronutrients that influence cellular stress responses in distinct ways.
- Copper maintained survival rates without impacting growth, while iron had similar survival effects.
- Iron chelation hindered growth and reduced the expression of genes related to energy production.
- Copper could partially reverse the negative effects of iron deficiency but needed iron to exert its benefits.
- Survival mechanisms for iron were dependent on active nutrient-sensing pathways, while copper functioned independently of these pathways.
- Copper activated different signaling pathways, including those involving energy regulation and antioxidants, compared to iron.
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